Diverse roles of androgen receptor (AR) domains in AR-mediated signaling
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چکیده
منابع مشابه
Diverse roles of androgen receptor (AR) domains in AR-mediated signaling
Androgens control male sexual development and maintenance of the adult male phenotype. They have very divergent effects on their target organs like the reproductive organs, muscle, bone, brain and skin. This is explained in part by the fact that different cell types respond differently to androgen stimulus, even when all these responses are mediated by the same intracellular androgen receptor. ...
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The androgen receptor (AR) gene is transcriptionally regulated by AR (autoregulation); however, the androgen response elements (AREs) required for this process have not been found in the AR promoter or in the 5'-flanking region. We previously showed that the AR cDNA contains AREs involved in AR mRNA autoregulation and that auto(up)regulation is reproduced in PC3 cells (a human prostate cancer c...
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ژورنال
عنوان ژورنال: Nuclear Receptor Signaling
سال: 2008
ISSN: 1550-7629,1550-7629
DOI: 10.1621/nrs.06008